Arrhythmia Treatment and Therapy

This vitally important reference traces the progress of antiarrhythmic drug trials and treatment methods-from the vantage point of the clinicians who designed and conducted the studies to objective views of the strengths and weaknesses of the results, identifying unresolved questions or newly created issues. Reviews significant studies in chronological order-providing a clear, informative account of how current thinking about arrhythmia treatment has evolved. Written by over 35 leading experts in the field, Clinical Trials on the Treatment of Arrhythmias emphasizes the need for science-based therapeutics and rigorously controlled clinical trials of drugs and implantable devices compares electrocardiographic monitoring with electrophysiological techniques for arrhythmia management analyzes the landmark Cardiac Arrhythmia Suppression Trial (CAST) evaluates the effectiveness of amiodarone describes sodium and potassium channel blockers and the development of drugs that slow conduction velocity and prolong repolarization and refractoriness investigates the effects of the d-isomer of sotalol on mortality critiques studies on the established efficacy of implantable devices versus amiodarone to benefit post-bypass surgery patients and more! Containing over 600 literature citations, Clinical Trials on the Treatment of Arrhythmias is an invaluable resource for cardiologists and cardiovascular specialists, pharmacologists, pharmaceutical researchers, and graduate and medical school students in these disciplines.